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KMID : 0895820050150030025
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Journal of Oriental Rehabilitation Medicine
2005 Volume.15 No. 3 p.25 ~ p.43
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Effects of J intong-san(Chentong-san) on the Adjuvant-Induced Arthritis and Expression of C-fos in Rats
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Son Dong-Woo
Kim Soon-Joong
Seo Il-Bok
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Abstract
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Objectives: This study was carried out to investigated the anti-pathogenetic and curative effects of Jintong-san(Chentong-san) on Complete Freund’s Adjuvant(CFA) induced arthritis in rats.
Methods: In experiment, Thirty male rats were divided into non-treated normal group(n=12), control group(n=12) is distilled water treated for 15 days after onset of arthritis by CFA, treated group(n=6) is Jintong-san(Chentong-san) treated for 15 days after onset of arthritis by CFA. Body weight, paw edema volume, and thickness of ankle joint were measured at 0, 5, 10, 15 days after treatment. At 15 days after treatment, IL-1β, IL-6 and PGE2 level in Paw Exudate were analysed for anti-inflammatory effect, C-fos immunoreactive cells measurement for analgesic effect, and histopathological examination was performed on the ankle joint.
Results: Paw edema volume, thickness of ankle joint, IL-1β, IL-6, PGE2, C-fos immunoreactive cells number of treated group was significantly decreased compared with control group and histopathologically, destructive lesions of articular cartilage and subchondral bony tissue, and degree of fibrous ankylosis in treated group were alleviated compared with those of control group.
Conclusions: These results indicated that Jintong-san(Chentong-san) has inhibitory effects on the progression of CFA arthritis in rats, by it’s lowering effects on the secretion of IL-1β, IL-6 and PGE2, and analgesic effect by C-fos immunoreactive cells decrease.
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KEYWORD
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Jintong-san(Chentong-san), Complete Freund’s Adjuvant, C-fos
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